Showing posts with label health. Show all posts
Showing posts with label health. Show all posts

Tuesday, September 6, 2011

110 Billion Deathless People

Damien: On Sunday, I raised the question “Must the end of death (except by accident or overwhelming infection or war) necessarily produce a vast population growth spurt?” It’s still not clear to me what the answer is, but the consensus of serious thinkers who’ve addressed this question appears to agree with me that it won’t be a major issue “for a long time—especially if many of the very long lived women are past their reproductive years.”

An interesting paper we’ll return to was published last year by the Russian husband and wife team Leonid A. Gavrilov and Natalia S. Gavrilova. Their paper, “Demographic consequences of defeating aging,” (presented at the Strategies for Engineered Negligible Senescence Conference, Queens' College, Cambridge, England, September, 2009), asks: “Is it possible to have a sustainable population dynamics in a future hypothetical non-aging society?” They show that in advanced societies, it’s the decline of populations that is the urgent issue, and even radical life extension for those past 60 will not bring us grief.

My point is that while men keep building new spermatozoa throughout their lives (and there are reports of men in their 90s become fathers), women have all their ova from before birth. Many eggs are pruned away by natural processes even before birth. They are obliterated at an extraordinary rate in the run-up to menarche. Then, around age 50 or so, menopause shuts down the female reproductive system as the last eggs vanish.

So if women are physiologically infertile after age 50 or 60, their indefinitely prolonged youthful life could not lead to additional babies from them. Unless radical steps are taken to implant a blastocyst into a medically prepared, hormonally rejigged uterus. This is not the kind of choice most women are eager to make, even if rejuvenation fixes routine cellular decay. It might become a choice after you’ve been alive for a century or two, and yearn to have another baby gurgling in the cot, but it seems unlikely to be widely adopted immediately by unaging but sterile women. (Just my guess; I might be wrong, and I’m biased because I have no kids of my own and don’t want any. Not yet, anyway.)

Now, this is an interesting consequence that I think is often overlooked in a too-simple calculation. I have the impression that a lot of people doing quick&dirty calcs on the impact of immortality treat it like compounding interest. But in compound interest, every existing dollar in your account contributes to future growth. That’s precisely not the case with an ageless future population of the kind I’m describing.

Let’s take the most extreme situation as a thought experiment. Suppose when Homo sapiens emerged, somewhere around 120,000 years ago, or more recently, repair and superior immunity mechanisms had evolved to complement intelligence. Imagine, then, that nobody had died, or aged beyond early adulthood, since then. Estimates of how many people have ever lived vary between 60 and perhaps 110 billion. Seven thousand million of those are now alive. So we might have lived in a world with perhaps 5 billion fertile men and woman and children yet to become fertile, plus 105 billion unaging people who do not themselves add to the increase in human numbers.

That is, the number of kids added to the Earth’s ecological load would be pretty much exactly the same as now. It’s just that there’d be 110 billion of us, rather than 7 billion. Nearly 16 times as many as now. Well, that’s a lot, but it’s not infinitely many. Still, is that even feasible, or would the world have collapsed long ago in a nightmare of resource wars, desperate crowding, and ecological despoliation?

Well, maybe not. If you’d lived for 100,000 years as a healthy 25-year old, would you necessarily be stuck digging insects out of a tree with a twig, or knapping stone? Hunter gatherers in the past century or two who entered advanced technological societies did not, by and large, remain aloof. Granted, for many it was a dreadful culture shock that destroyed their existing societies and languages, but that would not have happened in a deathless human world. Admittedly, known “primitive” cultures had truly atrocious murder rates, and maybe that would have persisted for a long time—but if so, that would have slowed the supposedly ruinous growth of human numbers. Meanwhile, we know that aggregations of people, especially cities of a certain size, tend to be the creative core of humanity. My guess is that we’d long ago have solved all the soluble problems of feeding, clothing, educating and amusing the world in as close to a Utopian way as we’ll ever manage.

If that’s true, it will come about in the same way during the next century or the next thousand years—once each of us has a realistic expectation of living indefinitely, healthy but increasingly wise with experience. And understanding, with slowly dawning horror, that it doesn’t make much sense to crap in your own nest, one you expect to live in for millennia.

The real test will be whether old minds in the new bottles of unaging flesh will retain the flexibility and joyous, infectious curiosity of youth, or will grow ever more in-turned, alienated, jaded and perhaps bitter and murderous. (“Get off my lawn, you kids!”) But long before that, I think, we’ll develop ways to tweak our own drives, to expand and edit our memories, to remain young at heart even as our bodies remain young in every other organ as well.

Friday, September 2, 2011

Staying Healthy for a Long, Long Time

Barbara: Professor Michael Rose at UC Irvine has written a provocative article for the latest issue of Cryonics Magazine.

He writes:

 I am not going to argue against cyberimmortality or cryo-immortality here.  After 
all, the value of back-up plans is self-evident.  Instead, what I am going to offer is an informal introduction to a third possibility.  This  possibility is one in which aging is stopped, and then repair and refurbishment are used to achieve immortality by the simple expedient of not dying in the first place.

Yeah, I always liked that Woody Allen quote about not wanting to achieve immortality through great works, but rather by not dying. A belief in physical immortality, or even living for, say, 200 years, might seem delusional. Rose would have thought so, as recently as three years ago, but no longer.

He became interested in the cessation of aging that occurs in animals toward the end of their life spans. Humans, he claims, stop aging at around age 100 (although other experts dispute this). Unfortunately, by the time they're that old, most people are in a pretty rotten condition. So Rose wondered if one might be able to halt the aging process at a younger age. Experiments with populations of fruit flies indicate that this is possible. In the last 30 years, Rose and his team have bred flies for longevity by choosing eggs only from the longest lived individuals--and his population of flies now live four times as long as ordinary wild flies.

Damien: So what's going on here? Rose used to believe that aging was the result of a trade-off between genes that promote health and vigor in youth but turn out to have bad consequences in later years. This notion was first advanced by evolutionary biologist George Williams more than half a century ago, but Professor Rose gave it the name used today: Antagonistic Pleiotropy. What's new and surprising, then, is that Rose no longer thinks Antagonistic Pleiotropy is a sufficient explanation for his robust ancient flies.

If he's right, changes in nutrition and lifestyle might allow people right now to maintain our current state of health indefinitely. That is, there'd be no clock relentlessly ticking away your fated lifespan, no necessary cumulative damage that dooms you to death. Mind you, Rose is not talking about rejuvenation. If you're 70, you'll stay that way--but you'll be the healthiest 70 year old it's possible to be, indefinitely. Rejuvenation might eventually be possible, using technology we don't yet possess (nanomachines in the bloodstream, say, to repair or remove damaged cells and keep organs as clean and fresh as an adolescent's), but we're nowhere near that yet. But Rose argues that we do already know how to halt aging. His company Genescient (co-founded by Dr. Cristina Rizza and physics professor and science fiction writer Gregory Benford) is making nutraceuticals (StemCell 100) designed with that in mind. Sooner or later, we'll know if it works.

Barbara: Rose's blog, Michael Rose's 55 is devoted to the possibilities of stopping the aging process of humans while we're still in good enough shape to enjoy life.